My Mayo blood draws are usually ay 6:30 am, and the neutrophil count was below 1000 at the end of both of the previous two cycles. In an afternoon blood draw a few days later, in both cases, the count had jumped up well above 1000 and I was able to continue on the study. This time, though, I was heading out of town to run a marathon, so we did another blood draw at Mayo before I left, still in the morning but not so early, hoping that it would show 1000 or above. But the vaunted Mayo Clinic screwed up! They did the CBC, but failed to do the differential which shows the actual absolute neutrophil count. By the time we discovered this, the test could not be repeated and we were almost halfway from Minnesota to Idaho. So the next day we stopped in Billings, MT, and had blood drawn there. I do not yet know the results of that CBC, so I can't be sure of continuing on the study. I'll assume the best unless I hear from Mayo.
I have been taking genistein, a soy isoflavone, throughout the pomalidomide trial, about 50 mg/day. It is supposed to have some anti-cancer effects by "supporting" the immune system. However, since myeloma is a cancer OF the immune system, there is a question whether it should be "supported," and in addition there are other questions about any estrogen-simulating supplement. So I decided to stop it for a cycle, to see what might happen to IgG and M-spike. I guess I got my answer. Back on genistein!
Three months ago I whacked the back of my left hand against something and got an infection, either bacterial or fungal, and the hand eventually got quite warm, swollen, and painful. It has healed very slowly, but it's almost better now.
Some current test results:
|Test||Mar 04||Apr 01||Apr 29||May 27||Remarks|
|M-spike g/dL||1.0||1.0||1.0||1.1||Best tumor measure|
|IgG mg/dL||1130||1070||1010||1110||Variation is normal|
|L FLC mg/dL||2.10||1.82||2.41||2.58||L Free light chains|
|Calcium mg/dL||10.1||9.8||9.7||9.9||Below 10.2 is best|
|Creat mg/dL||1.0||1.2||1.3||1.3||Kidney, normal|
|HGB g/dL||14.2||14.7||14.6||14.1||Hemoglobin, normal|
|RBC M/uL||4.17||4.39||4.21||4.36||Red cells, normal|
|WBC cells/uL||3400||3300||3300||3600||White cells, low|
|ANC cells/uL||1290||940||730||920||Neutrophils, LOW!|
I have been invited to attend the annual meeting of the American Society of Clinical Oncologists next week, and I will be blogging in "real time" about the presentations that I see there. Here are a few of the topics that seem interesting to me:
- Studies of Carfilzomib, a Velcade-like drug which has far fewer side effects;
- Post-transplant maintenance therapy with Revlimid or another drug, versus no maintenance. We're going to hear that maintenance prolongs lives!;
- Denosumab versus Zometa for bone problems;
- More about pomalidomide (when will they get this FDA approved?);
- Doxil, Velcade, and dexamethasone as front-line therapy; and
- LOTS more. I can't hope to cover it all.
|My Myeloma||A discussion of my myeloma, not very technical.|
|My Treatment History||Not technical.|
|My Test Charts||Graphic displays of several key test results over time.|
|My Test Result Table||Best with a wide browser window. Somewhat technical.|
|My Supplement Regimen||With links to where I buy them.|
I haven't had time to update the charts, test results table, and other documents (see links above) that go with this post, but wanted to get this posted now while I have a few minutes. I'll get around to the rest later, but there is really not a lot of change except the increase in IgG and M-spike.
P.S. June 2, 2010: The blood test (CBC) at Billings Clinic showed 1890 little guys per microliter (how can it go up that much from 920 in one day?) so I'm still on the study!