CC-4047 side effects for me:
- Bradycardia - my resting heart rate has dropped from about 48 to about 41.
- Slight reduction in red cell count and hemoglobin, taking both just below the reference range.
- Tinnitus from the aspirin that I take with the CC-4047.
Dexamethasone side effects:
- "Peppy" and not-so-peppy days, fitful sleep one day a week.
- Increase in belly fat - I'm pretty sure this is happening.
- Loss of muscle mass, especially quads - my running speed is declining.
- High blood sugar levels on "dex day," as measured with glucose monitor.
- Thinning of my skin; it seems quite fragile now.
- Dex voice (tight).
I'm lucky, or blessed, in so many ways. Though I can't run as fast as I once could, that's unimportant in the big picture. Most important, myeloma has not yet hurt me. Aside from painless lesions inside three bones, I have no symptoms from the disease itself, and symptoms from the treatment are quite livable thus far. I wish that all myeloma survivors were so lucky, or blessed. Thank you for your prayers, and I offer you mine.
- My Myeloma A discussion of my myeloma, not very technical.
- My Treatment History Not technical.
- My Test Charts Graphic displays of several key test results over time.
- My Test Result Table Best with a wide browser window. Very "technical."
- The loss of muscle mass and the thin skin, both caused by dex, may be reversible if I can ever stop using dex.
- There is not enough information yet on CC-4047, or on its relative Revlimid, to know if either drug is likely to cause other cancers or to change the myeloma to a more aggressive type. So far so good.
- The absolute amount of drop in IgG and M-Spike seems to be somewhat less for each successive cycle, and that trend is likely to continue. It's the direction that is important. I notice that the drop in IgG as a percentage of the previous measurement has been about the same from cycle to cycle, about 25%.
- I expressed the view that since the current treatment is working and there are lots of other treatments available, I might expect not to die from myeloma for five or ten years even without any advances in treatment. Dr. L thought that was not an unrealistic expectation. Cool.
- We talked about running a little too. :-)
Tonight's celebration salad: Organic romaine, cucumber, organic walnuts, avocado, organic strawberries, blue cheese, organic red wine vinegar, organic pomegranate juice.