Sunday night I took the "usual" 40 mg dose, ten little 4 mg tablets, at bedtime. In the past this has worked OK for me because the DEX doesn't interfere with my sleep that first night. And it didn't interfere Sunday night, I slept well. Monday, then, was "DEX day," full of energy, as if 200% caffeinated all day. I got a lot done, including an energetic 4-mile walk/run.
Trouble started at bedtime Monday night. Never in my life have I had such heartburn - was that from the DEX? I suppose so, I think so. I slept very little that night, awake because of the DEX and forced to sit up for part of the night to ease the acid reflux. In the morning my esophagus was still inflamed, warm coffee causing pain when it reached the bottom.
Tuesday became another DEX day, my body once again on full alert. I tried for a much needed nap, but no dice. Again I got a lot done, rounding up materials for a wood duck house that we are building for our back yard, and preparing for our upcoming 93rd marathon, but I felt like I was running on empty. Tuesday night I did finally fall asleep after a couple of restless hours, but awoke again at 4:00 am only to lie there until rising.
Wednesday was strange. I felt like someone else, I don't know who. Not sick, but not OK. I did finally get an afternoon nap, and Wednesday night I was able to sleep, waking Thursday morning mostly recovered.
I really don't want to have that experience again, especially the acid reflux, which might actually have caused permanent injury at the bottom of the esophagus. I know that the doctors believe that the 40 mg dose of DEX is more effective than a lower dose, but I wonder if it is worth the unpleasantness and, indeed, the risk. I can try to manage the acid reflux by finishing the supper meal at least two hours before bedtime, and skipping my usual one beer and all chocolate. I will take calcium citrate morning and evening, and perhaps eventually take a prescription remedy if necessary - I don't have such a prescription yet and don't know if there really is an effective one.
The current plan is to take the full 40 mg once more this coming Sunday and see how it goes. Sigh.
In other news I am now taking Pomalyst once again, 2 mg daily. This can suppress neutrophils, but a CBC on Wednesday showed them at 5.2 k/uL, which is about twice what my neutrophils usually run. I don't know why - does DEX help with neutrophils? A quick Google search suggests that it may indeed help, possibly one of the reasons that "everything works better with DEX." Oh well, let's try one more week.